Principal Research Scientist, QTAS & ADME Sciences
Core
Lead scientific strategy and execution for in vitro ADME (Absorption, Distribution, Metabolism, and Excretion) and DMPK projects to support drug candidate advancement.
Role type
Principal Research Scientist (Scientific Leadership)
Builds
Translational mechanistic models for early and late-stage small molecules
Domain
Pharmaceutical R&D, Drug Metabolism and Pharmacokinetics (DMPK)
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
in vitro ADME experiments, drug metabolism principles, enzyme kinetics, IVIVE, DDI risk assessment, strategic scientific leadership, publication record
Preferred skills
drug permeability, transport, receptor pharmacology, pharmacokinetic modeling, new technology implementation
Technologies
in vitro assays, quantitative bioanalysis, mechanistic modeling
Responsibilities
Evaluate novel in vitro tools and methods to predict human PK and DDI potential; Lead, mentor, and coach junior staff in in vitro drug metabolism practices; Liaise with discovery biology/pharmacology/chemistry scientists to generate data for translational models; Communicate internally and externally on in vitro drug metabolism topics; Contribute to full-length publications and oral presentations.
Seniority
Principal, strategy & mentorship