Modelling and Simulation PK/PD Expert
Core
Design and oversee complex preclinical studies using mathematical modelling to predict human pharmacokinetics/pharmacodynamics and inform dosing strategies for cardiovascular, renal, and metabolic disease treatments.
Role type
Senior IC PK/PD modelling expert (translational/preclinical)
Builds
Quantitative insights for target/molecule selection, dosing regimens, and translational development decisions
Domain
Biopharmaceutical R&D, Cardiovascular/Renal/Metabolic therapeutics
Deliverable
production ML models
Required skills
Model-based PK/PD, NLME, PBPK, QSP, R, Python, MATLAB, Phoenix, Monolix, NONMEM, AI/ML for quantitative research
Preferred skills
Preclinical/translational PK/PD modelling, multi-modality strategy (small molecules, oligonucleotides, peptides, proteins, antibodies, CGT), Simcyp, PK-Sim
Responsibilities
Design and execute complex preclinical disease model studies; synthesize multi-source data to predict human PK/PD; present quantitative assessments to senior stakeholders; lead strategic DMPK and PK/PD innovation projects
Seniority
Senior, hands-on IC with scientific leadership