Senior Scientist, ECM biology and 3D models
Core
Investigate ECM remodelling mechanisms in fibrosis and cancer, develop translational tissue-derived and 3D disease models, and validate therapeutic targets.
Role type
Senior Scientist, ECM biology and 3D models
Builds
Translational tissue-derived and ECM-based 3D disease models for target validation and therapeutic testing
Domain
Biotechnology, Fibrosis, Oncology, Extracellular Matrix Biology
Required skills
ECM biology, tissue-derived model development, 3D cellular model development, primary stromal-cell handling, imaging and tissue analysis, biochemical and molecular biology techniques, proteomics/peptidomics
Preferred skills
Fibrosis, oncology, translational drug discovery experience
Technologies
Precision-cut tissue slices, decellularised matrices, hydrogel-based systems, immunofluorescence, qRT-PCR, western blotting, MSD immunoassays
Responsibilities
Drive experimental studies on ECM remodelling mechanisms, develop and optimize tissue-derived and 3D disease models, establish functional readouts for target discovery, support proteomic approaches, collaborate with data-science teams, analyze experimental data
Seniority
Senior, hands-on IC