Head of In Vitro Pharmacology
Core
Establish in vitro pharmacology capabilities and lead cell-based assay design, execution, and analysis to support small molecule drug discovery from hit identification to candidate nomination.
Role type
Head of In Vitro Pharmacology (Lead IC)
Builds
High-quality in vitro pharmacology data packages and IND-enabling data supporting med chem optimization and candidate nomination.
Domain
Biopharmaceuticals / Small molecule drug discovery / In vitro pharmacology
Required skills
Cell-based assay design and execution, Cell line engineering and characterization, High-throughput screening strategy, Molecular and cellular biology techniques, Automation and liquid handling systems, Data analysis and interpretation, Team leadership and mentorship, Project management in drug discovery
Preferred skills
CRO operating environment experience, Targeted protein degradation modalities (PROTACs), DMPK interface knowledge, IND-enabling or GLP-compliant environment experience
Technologies
NanoBRET, NanoBiT, TR-FRET, AlphaScreen, luminescence, reporter gene activation, FLIPR, Western blot, qPCR, gene editing, siRNA knockdown, biomarker assays, liquid handling systems
Responsibilities
Define and lead design, execution, and analysis of cell-based assays; Select, engineer, and characterize disease-relevant cell lines; Design strategies for high-throughput screening campaigns; Apply molecular and cellular biology techniques to evaluate compound activity and mechanism of action; Lead and mentor a team of research associates and scientists; Collaborate with cross-functional drug discovery teams; Align scope and timelines for med chem optimization; Lead implementation of automation and liquid handling systems
Seniority
Senior, hands-on IC with leadership mandate