2027 Summer Intern - In Vitro Safety & Neurotoxicology
Core
Optimize and qualify a human iPSC-derived neuronal co-culture assay on high-density microelectrode array (MEA) platforms to predict compound-induced seizure liability and neurotoxicity.
Role type
Summer intern, in vitro safety & neurotoxicology
Builds
Predictive toxicology data for early drug discovery pipelines
Domain
Biotechnology / Neuroscience / Toxicology
Required skills
aseptic cell culture techniques, iPSC-derived neuronal culture, microelectrode array (MEA) systems, electrophysiology concepts, compound dosing studies, multi-parametric electrophysiological data analysis
Preferred skills
electrophysiology data analysis software (Axion, R, Python), cross-functional collaboration
Responsibilities
Onboard and optimize MEA experimental protocols for iPSC-derived neuronal cultures; Qualify the MEA assay using reference pro-convulsant and non-convulsant compounds; Analyze complex neural spike and burst metrics to establish robust endpoints; Collaborate with cross-functional teams to integrate MEA assay workflows; Present experimental findings and validation data at meetings