Principal Scientist – Translational Medicine (Tumor Microenvironment)
Core
Designing, developing, and implementing pharmacodynamic and predictive biomarker strategies across early- and late-stage clinical trials for oncology therapeutics, while leading hypothesis-driven translational research to identify novel biomarkers of therapeutic response and resistance.
Role type
Principal Scientist (Translational Medicine / Oncology)
Builds
Clinical development programs for oncology therapeutics
Domain
Oncology / Translational Medicine / Biomarker Discovery
Required skills
Translational research design, multi-omic profiling, spatial biology, single-cell technologies, functional immune assays, advanced quantitative analysis, computational methods, hypothesis generation, mechanistic insight generation, scientific writing, cross-functional collaboration
Preferred skills
Tumor microenvironment biology, prostate cancer expertise, R, Python, AI-enabled analytical approaches
Technologies
R, Python, agentic AI tools, multi-omic platforms, spatial biology tools, single-cell sequencing platforms
Responsibilities
Develop and execute biomarker strategies from first-in-human through registrational studies; Partner cross-functionally with Research, Clinical Development, and Diagnostics; Deploy next-generation biomarker assays; Design translational research plans leveraging clinical samples and emerging AI tools; Contribute mechanistic understanding of tumor microenvironment dynamics; Integrate complex biological datasets to generate clinically actionable insights; Write and review clinical protocols, study reports, and manuscripts; Publish research in leading scientific journals.
Seniority
Principal, hands-on IC with strategic leadership