Principal Scientist, Structural Biology
Core
Lead structural biology strategy and execution to uncover structural and dynamic mechanisms of therapeutic target proteins, integrating structural data, computational modeling, and biophysical insights to enable drug discovery.
Role type
Principal Scientist, Structural Biology (Strategy & Execution)
Builds
Drug discovery pipelines for therapeutics
Domain
Biopharmaceuticals / Structural Biology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery
Required skills
protein dynamics characterization, molecular dynamics simulation, structural ensemble modeling, ensemble docking, cryoEM, X-ray crystallography, protein construct design, ligand optimization, target assessment, hit finding, lead identification
Preferred skills
protein construct design and purification workflows, virtual docking, free energy perturbation (FEP), protein language models, machine learning for protein design, laboratory automation
Technologies
cryoEM, X-ray crystallography, molecular dynamics simulation, structural ensemble modeling, ensemble docking, virtual docking, free energy perturbation (FEP)
Responsibilities
Lead structural biology strategy and execution within multi-disciplinary drug discovery project teams; oversee protein construct design, expression, purification, and high-resolution structure determination; solve and analyze structures of target protein complexes bound by small molecules, peptides, antibodies, or other therapeutic formats; utilize computational tools alongside experimental data to characterize dynamics of biological macromolecules; translate protein dynamics insights into actionable strategies for target assessment, construct design, and lead optimization; empower and mentor colleagues in applying computational tools and dynamics/ensemble methods.
Seniority
Principal, strategy & mentorship