Principal Scientist, Structural Biology
Core
Lead structural biology strategy and execution to uncover structural and dynamic mechanisms of therapeutic target proteins for drug discovery.
Role type
Principal Scientist, Structural Biology (Senior IC with mentorship)
Builds
High-resolution structures of protein complexes and actionable structural insights for target assessment and lead optimization
Domain
Biopharmaceuticals / Structural Biology / Drug Discovery
Required skills
protein dynamics characterization, molecular dynamics simulation, structural ensemble modeling, ensemble docking, cryoEM, X-ray crystallography, protein construct design, protein purification, ligand binding analysis, target identification, pocket discovery, binder discovery, lead optimization
Preferred skills
virtual docking, free energy perturbation (FEP), protein language models, machine learning for protein design, computational automation
Technologies
cryoEM, X-ray crystallography, molecular dynamics, ensemble docking, FEP
Responsibilities
Lead structural biology strategy within multi-disciplinary drug discovery teams; oversee protein construct design, expression, purification, and structure determination; solve and analyze structures of target protein complexes; utilize computational tools to characterize macromolecular dynamics; translate insights into strategies for hit finding and lead optimization; mentor colleagues in applying computational tools and dynamics methods
Seniority
Principal, strategy & mentorship
