Scientist | AAV vectors for target validation research
Core
Develop and optimize AAV vectors for target validation and disease model establishment in early drug discovery.
Role type
Scientist, AAV vector production and target validation
Builds
AAV preparations, optimized vector systems, and preclinical disease models
Domain
Biopharmaceuticals, Gene Therapy, Molecular Biology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
AAV vector production and purification, vector optimization (capsid, expression cassette), in-vivo gene modulation strategies, molecular and cell biology methods, CRISPR/Cas9 design, disease mechanism understanding, scientific publication record
Preferred skills
Experience with other vector systems (Lentiviruses, LNPs), animal handling, tissue sample processing, German language
Technologies
qPCR, In-situ hybridization, Sequencing, Immunohistochemistry, CRISPR/Cas9
Responsibilities
Produce, purify, and analyze AAV preparations; Optimize and implement process improvements; Develop and characterize AAV vectors for tissue targeting; Apply DNA/RNA/protein analysis methods to interpret results; Design expression constructs for in-vivo gene modulation
Seniority
Senior, hands-on IC
