Biologe (m/w/d)
Core
Establishing, optimizing, and standardizing differentiation protocols for induced pluripotent stem cells (iPSCs) into hematopoietic and immune effector cells (NK/T cells), scaling processes to bioreactors, and transferring technologies to GMP manufacturing.
Role type
Senior IC iPSC process development scientist (cellular therapy)
Builds
Allogeneic cell therapy products (NK/T cells) via GMP-compliant manufacturing
Domain
Biotechnology / Cellular Therapy / Immunology
Required skills
iPSC differentiation protocols, scale-up of mammalian cell cultures, GMP manufacturing for ATMPs, bioreactor operation (stirred-tank, rocking-motion), cell line evaluation, Master Cell Bank establishment, non-viral transfection, perfusion systems
Preferred skills
Experience with human embryonic stem cells (hESCs), academic collaboration, Freedom-to-Operate (FTO) assessment
Technologies
Rocking-Motion bioreactors, Stirred-Tank bioreactors, Closed Systems, Reinraumklasse C/D, non-viral transfection, Cytokine cocktails
Responsibilities
Develop and standardize iPSC differentiation protocols for hematopoietic and immune cells; Scale up adherent cultures to suspension processes in bioreactors; Evaluate external iPSC lines for clonal stability and differentiation potential; Collaborate with QA/QC/CMC teams to implement GMP-compliant manufacturing processes; Identify and implement innovative technologies to improve process efficiency and scalability
Seniority
Senior, hands-on IC