Director, Protein Engineering, Discovery Portfolio
Core
Lead the design and optimization of therapeutic proteins (antibodies, conjugates, fusion proteins) to support discovery programs in Oncology, Immunology, Cardiovascular, and Neuroscience.
Role type
Senior IC Director of Protein Engineering (Discovery)
Builds
Therapeutic protein molecules and development candidates
Domain
Biopharmaceuticals / Protein Engineering / Drug Discovery
Deliverable
production ML models
Required skills
Therapeutic protein engineering, Multispecific design, Structure-function reasoning, Program leadership, People leadership, Cross-functional strategy alignment
Preferred skills
Fc engineering, High-throughput expression workflows, Structure-based modeling (Rosetta, FoldX), Generative AI/ML-driven design (AlphaFold 3, RFdiffusion), Active learning/Bayesian optimization
Technologies
Rosetta, FoldX, MOE, Schrödinger, PyMOL, AlphaFold 3, RFdiffusion, ProteinMPNN, ESMFold
Responsibilities
Lead the protein engineering team and set scientific direction; Own engineering strategy on discovery programs from concept to lead optimization; Co-develop computational–experimental design strategy with ML leaders; Partner with therapeutic area strategy to align engineering with biology; Serve as interface to Protein Sciences and Development; Champion sequence–structure–assay data quality and manage external collaborations
Seniority
Director, strategic leadership with hands-on scientific expertise
