Senior Associate Scientist, Synthesis, RNA Process Sciences
Core
Define early process conditions and scale down process development for RNA drug substance synthesis (circular and linear mRNA) to improve yield, quality, and robustness.
Role type
Senior Associate Scientist, RNA Process Sciences
Builds
RNA drug substance for preclinical to early-stage clinical development
Domain
Biopharmaceuticals / mRNA therapeutics
Required skills
in vitro transcription, circularization, DNase reactions, automated liquid handlers, small scale stir tank reactors, statistical design of experiments (DoE), multivariate data analysis, HPLC, capillary electrophoresis (CE), gel electrophoresis, process analytics, biophysical characterization, cGMP, ICH guidelines, QbD principles
Preferred skills
scripting languages for instrument control, LIMS/ELN systems, process investigations, mechanistic modeling, lipid chemistry, nucleic acid chemistry
Responsibilities
Perform early optimization and characterization of RNA synthesis reactions; Support RNA drug substance synthesis process definition and scale up; Execute high throughput/automated experiments; Confirm robust process performance across control space; Collaborate with research teams for tech transfer to GMP manufacturing; Prepare technical reports and communicate findings
Seniority
Mid-level (BS +4 years or MS +2 years), hands-on IC