Senior Scientist, Bioconjugation & Targeted Nanomedicine
Core
Design, develop, and optimize bioconjugation strategies and targeting ligand architectures for next-generation targeted nanoparticles to enable selective, cell type-specific delivery of therapeutics.
Role type
Senior Scientist, Bioconjugation & Targeted Nanomedicine
Builds
Targeted nanoparticle delivery systems for treating hematologic malignancies, solid cancers, and autoimmune diseases
Domain
Life Sciences / Nanomedicine / Chemical Biology
Required skills
Bioconjugation chemistry, Linker chemistry, Analytical characterization (LC-MS, HPLC/UPLC, SEC, IEX, HIC, SDS-PAGE), Protein engineering, Nanoparticle system design, Biomolecular format expertise (antibodies, peptides, fragments)
Preferred skills
Therapeutic conjugate platform experience (ADCs, oligonucleotide conjugates), Cross-functional collaboration, Scientific communication, Mentorship
Technologies
LC-MS, HPLC/UPLC, SEC, IEX, HIC, SDS-PAGE, UV/Vis, AKTA-based chromatography
Responsibilities
Design and develop bioconjugation strategies for targeted nanoparticles across various ligand formats; Develop and optimize conjugation chemistries and linker strategies; Contribute to targeting ligand engineering and sequence-level modifications; Develop analytical workflows to characterize bioconjugates; Integrate targeting ligands into nanoparticle systems and characterize delivery performance; Collaborate cross-functionally to translate molecular design into delivery performance; Provide scientific mentorship to junior scientists
Seniority
Senior, hands-on IC