Scientist, Purification, RNA Process Development
Core
Designing efficient, robust, and scalable manufacturing processes for RNA drug substances (circular and linear mRNA) by developing and characterizing chromatography and filtration steps.
Role type
Scientist, RNA Process Development (Purification)
Builds
RNA drug substance purification processes for clinical manufacturing
Domain
Biopharmaceuticals / mRNA therapeutics
Required skills
Chromatography, Filtration (TFF/UF-DF), Statistical Design of Experiments (DoE), Process Analytics, Biophysical Characterization (HPLC, CE, Gel Electrophoresis), cGMP/ICH/QbD principles, Technical Reporting
Preferred skills
Nucleic acid chemistry, Lipid chemistry, Scale-down modeling, Mechanistic modeling
Responsibilities
Design, execute, and analyze experiments for existing and novel process modes using DoE; Define purification process parameters and design space; Collaborate with upstream PD to characterize IVT feed stream; Participate in tech transfer activities to GMP manufacturing sites
Seniority
Mid-level (BS+6yrs, MS+4-6yrs, PhD+0-2yrs), hands-on IC