Principal Scientist, Cell Therapy Translational Biology Research
Core
Lead laboratory-based research for clinical-stage cell therapy assets in oncology and autoimmune indications, translating biology into clinical and regulatory decisions.
Role type
Principal Scientist, Cell Therapy Translational Biology
Builds
Non-clinical data packages, novel in vitro assays, and regulatory documents for cell therapy programs
Domain
Biotechnology / Cell Therapy / Oncology / Autoimmune
Required skills
Experimental design and execution, Mechanism of action studies, Biomarker identification, Patient stratification, In vitro assay development, Manufacturing process comparability, Regulatory document writing, Cross-functional collaboration, Technical mentorship, Data presentation
Preferred skills
Immunology expertise, Flow cytometry, Cell culture and imaging, High content data analysis (transcriptomic/proteomic), Electronic Lab Notebooks (ELN), Drug development lifecycle knowledge
Technologies
Incucyte, JMP, GraphPad Prism
Responsibilities
Develop and lead focused research projects with independent judgment; Plan, direct, and execute laboratory research to characterize product function; Design and lead non-clinical/translational data packages for regulatory submissions; Contribute to biomarker strategy and patient stratification; Lead development of novel in vitro assays; Investigate impact of manufacturing changes on product comparability; Represent team on cross-functional program teams; Write non-clinical pharmacology reports and regulatory documents; Coordinate external collaborations; Mentor junior scientists; Present data at meetings and contribute to manuscripts/patents; Support lab stewardship initiatives
Seniority
Principal, hands-on IC with mentorship