Principal Scientist, Engineered Cell Therapy Discovery
Core
Leading the discovery and optimization of novel engineered CAR T and eTCR T cell therapeutics for cancer and chronic diseases.
Role type
Principal Scientist, Engineered Cell Therapy Discovery
Builds
Next-generation engineered cell-based therapies
Domain
Biopharmaceuticals / Cell Therapy / Immunology
Required skills
Immunology, Cell therapy, In vitro functional screening (cytotoxicity, cytokine production), Logic-gated CAR T/eTCR circuit design, Gene delivery (lentiviral, retroviral, AAV), Genetic construct optimization, In vivo xenograft studies, Multidisciplinary team leadership, IND-enabling study reporting, Patent applications, Multi-color flow cytometry, Molecular biology (cloning, library generation)
Preferred skills
Postdoctoral research experience, Independent research program leadership, Complex matrixed cell therapy program management, Peer-reviewed publications in immunology/cell therapy
Technologies
Lentivirus, Retrovirus, AAV, Gibson Assembly, Golden Gate, Flow cytometry
Responsibilities
Set strategic direction for research programs on engineered CAR T and eTCR T cell therapies; Lead in vitro functional screening to evaluate and optimize T cell therapies; Design and optimize genetic constructs and gene delivery approaches; Mentor and develop junior scientists; Translate in vitro data into in vivo xenograft studies; Lead multidisciplinary collaborations across wet lab, computational, and clinical functions; Drive go/no-go decision-making and represent research strategy to senior leadership; Contribute to IND-enabling study reports, patent applications, and peer-reviewed publications.
Seniority
Principal, strategy & mentorship