Principal Scientist (all genders) Structural Biology
Core
Provide scientific leadership in interdisciplinary projects to elucidate structural mode of action and enable structure-based design for macromolecular complexes of antibodies, multispecifics, and molecular degraders.
Role type
Principal Scientist (Structural Biology)
Builds
Integrated, end-to-end experimental strategies for structural enablement spanning protein and sample generation, data acquisition, and structural model building.
Domain
Life Science / Structural Biology / Drug Discovery
Deliverable
production ML models
Required skills
X-ray crystallography, cryo-EM, protein complex analysis, CRO coordination, scientific communication, mentoring, LINUX scripting, cloud-based data management
Preferred skills
AI/ML-based prediction of biomolecular structures, biophysical techniques (HDX-MS, SAXS, Refeyn, FIDA, DSF), oncology/immunology/neuroscience drug discovery experience
Technologies
X-ray crystallography software, cryo-EM, HDX-MS, SAXS, Refeyn, FIDA, DSF, LINUX, cloud platforms
Responsibilities
Design and execute complex structural biology projects; strengthen X-ray crystallography capabilities; coordinate CRO and collaboration partner activities; communicate scientific findings to cross-functional teams; mentor junior scientists.
Seniority
Principal, scientific leadership & mentorship
