Senior Scientist, Antibody Conjugation
Core
Build a new antibody conjugation capability from the ground up, developing and validating bioconjugation chemistries for attaching degrader payloads to antibodies for advanced in vivo and translational studies.
Role type
Senior Scientist, Antibody Conjugation (Hands-on IC)
Builds
Study-ready antibody-drug conjugates (ADCs) and bioconjugates for pharmacology and PK/PD studies
Domain
Biopharmaceuticals / Antibody-Drug Conjugation (ADC) / Chemical Biology
Required skills
Antibody/protein bioconjugation chemistry (NHS ester, maleimide, click chemistry, site-specific conjugation), FPLC/AKTA purification, TFF, column chromatography, LC-MS analysis, protocol development for automation, scale-up synthesis (mg to multi-mg)
Preferred skills
Experience with liquid-handling platforms (Hamilton, Tecan), automated synthesis workflows, computational chemistry collaboration
Technologies
FPLC/AKTA, TFF, SEC, IEX, RP-HPLC/UPLC, HIC, LC-MS, Hamilton, Tecan
Responsibilities
Develop and optimize antibody bioconjugation methods for attaching degrader payloads and linkers; Design conjugation chemistry protocols for transfer to liquid-handling platforms; Execute one-off and scale-up conjugation runs; Purify conjugates and troubleshoot yield/homogeneity/stability; Write SOPs and train automation team; Collaborate cross-functionally with medicinal, analytical, and computational chemists
Seniority
Senior, hands-on IC
