Technical Research Assistant I
Core
Develop a spatial molecular atlas of therapeutic targets in rare pediatric and adult brain tumors using multiplexed tissue-imaging and quantitative analysis.
Role type
Technical Research Assistant I (translational cancer research)
Builds
Spatial molecular atlases and validated antibody panels for rare brain tumor therapies
Domain
Oncology / Molecular Imaging / Quantitative Pathology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
multiplexed tissue-imaging, immunofluorescence, immunohistochemistry, antibody development and qualification, quantitative image analysis, FFPE tissue preparation, spatial transcriptomic data integration, experimental record keeping, protocol optimization
Preferred skills
experience with CyCIF, ORION, ImageJ/Fiji, Python, R, MATLAB, patient-derived tumor models, xenograft models
Technologies
CyCIF, ORION, ImageJ/Fiji, Python, R, MATLAB
Responsibilities
Generate and analyze multiplexed tissue-imaging data across tumor types; Develop and qualify antibodies against therapeutic targets; Design and optimize multiplex antibody panels; Prepare and analyze human FFPE tissue specimens and patient-derived models; Perform quantitative analysis of whole-slide images including segmentation and heterogeneity evaluation; Integrate protein-imaging results with spatial transcriptomic data; Troubleshoot and optimize experimental protocols; Prepare figures and datasets for scientific publications; Support routine laboratory activities and safety procedures
Seniority
Early-career, hands-on IC
