Post Doctoral Research Fellow
Core
Conduct independent research on cellular and molecular mechanisms of psychiatric disorders using advanced microscopy and integrate findings with clinical phenotypes, while managing the McLean Hospital Microscopy Core facility.
Role type
Postdoctoral Research Fellow and Microscopy Core Manager
Builds
Research insights on stress/immune signaling in the neurovascular unit; operational capacity of the shared microscopy facility
Domain
Translational Neuroscience / Psychiatric Research / Advanced Microscopy
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Advanced microscopy techniques (fluorescence, confocal, two-photon, electron), quantitative image analysis, 3D reconstruction, multiplex in situ RNA/protein detection, cell culture (primary human astrocytes/microglia/endothelial cells), iPSC-derived cell models, single-cell/single-nucleus transcriptomics, grant writing, scientific presentation
Preferred skills
Experience with human postmortem brain specimens, natural-language-processing for clinical data integration, budgeting, vendor liaison
Technologies
Reichert-Jung ultramicrotome, JEOL JEM1200EX TEM, cryopreservation systems, electron tomography software
Responsibilities
Perform advanced microscopy and image analysis on human brain tissue; manage microscopy core operations, instrument maintenance, and user training; conduct TEM studies and sample preparation; integrate molecular/cellular data with clinical phenotypes; prepare manuscripts and grant applications
Seniority
Postdoctoral Fellow (early-career researcher with independent project leadership)