Post-doctoral Research Fellow, Orthopaedic Infection Research
Core
Develop antibacterial controlled release devices and test methods for total joint replacements to address periprosthetic joint infections using materials science and translational research.
Role type
Post-doctoral research fellow (IC)
Builds
Preclinical disease and surgery models for orthopaedic implant safety and efficacy
Domain
Orthopaedics / Microbiology / Materials Science
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Microbiology of Staphylococcus aureus and epidermidis, gram-negative bacteria, BSL2 lab safety, in-vitro host-pathogen models, bacterial/host transcriptomics, DNA/RNA extraction, Real-time PCR, NGS Library prep, RNA-Seq, Fluorescence/Confocal/Live/Electron microscopy, Drug susceptibility testing (MIC/MBC/MBEC), polymer synthesis methods
Preferred skills
Bacterial transcriptomics, bioinformatic analyses, analytical chemistry, polymer synthesis methods
Technologies
VITEK, NGS, Real-time PCR, SEM, TEM, Flow cytometry, Microplate-based assays
Responsibilities
Establish monomicrobial and polymicrobial cultures for musculoskeletal infections; characterize bacteria (planktonic and biofilms) using bacteriological techniques and flow cytometry; characterize antibiotic resistance, tolerance, and virulence; establish cell cultures and perform molecular/biochemical assays; perform molecular characterization of pathogens and host responses; conduct advanced microscopy; analyze bacterial transcriptomics; study host-pathogen interactions using in vitro and in vivo models; perform drug susceptibility testing and antibacterial/anticolonization studies; design in-vitro periprosthetic joint infection models; supervise biomedical research engineers; collaborate on device formulation and preclinical studies
Seniority
Post-doctoral, hands-on IC