Vodilni raziskovalec I / Principal Scientist I
Core
Lead downstream processing of recombinant proteins (monoclonal and multispecific antibodies) from CHO cultures to enable lead candidate selection for biologics.
Role type
Principal Scientist I, Downstream Processing
Builds
Biotherapeutic modalities for Novartis Biomedical Research and Development
Domain
Biopharmaceuticals / Recombinant Protein Production
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Downstream processing of monoclonal and multispecific antibodies, liquid chromatography (Aekta systems), filtration, centrifugation, experimental design, data analysis workflows, project prioritization, resource management
Preferred skills
CHO cell culture, Upstream Processing
Technologies
Aekta systems, liquid chromatography, filtration, centrifugation
Responsibilities
Coordinate and execute downstream processing of recombinantly expressed proteins from suspension CHO culture (small to large scale up to 200L), act as senior production expert and lead in project teams, drive therapeutic protein production strategy in R&D Mengeš, drive and lead technology projects for protein purification and conjugation, foster streamlined processes and optimal use of capacities, manage resources and project timelines, provide leadership and guidance to the team
Seniority
Principal, hands-on IC with team leadership
