Principal Scientist, Biomarker Assay Development Bench Scientist
Core
Design, develop, and qualify preclinical and clinical biomarker assays (cellular, soluble, proteomic, genetic, genomic) to support target engagement, pharmacodynamics, and patient stratification for drug discovery and development programs.
Role type
Principal Scientist, bench research IC
Builds
Preclinical and clinical biomarker assays for renal, liver, fibrosis, and exploratory indications
Domain
Biopharma / Biomarker Assay Development
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Ligand binding assay (LBA) design and execution, biomarker assay development, proteomics, genetics, genomics, biochemical and cellular assay development, assay qualification and implementation, analytical rigor, scientific rigor, troubleshooting
Preferred skills
Multiomics profiling, patient stratification approaches, animal models, ex vivo assays, RNA assays, LC-MS based quantification, statistics, computational data analysis, CRO/vendor management
Technologies
ELISA, MSD, immunoassays, LC-MS
Responsibilities
Design and execute laboratory-based research including hands-on assay development and optimization, analyze and interpret experimental data, collaborate with Translational Medicine and project teams, support assay implementation in studies, maintain laboratory practices and safety guidelines, present research findings
Seniority
Principal, hands-on IC with strategic expertise