Principal Scientist, Pharmaceutical Development
Core
Senior technical leader providing scientific expertise, technical oversight, and strategic guidance for preformulation and pharmaceutical development across multiple drug development programs from early discovery to clinical development.
Role type
Principal Scientist, Preformulation & Pharmaceutical Development
Builds
Drug candidates advancing to Phase I/II clinical trials
Domain
Biopharmaceuticals, Neurological/Psychiatric/Endocrine/Immunological disorders
Required skills
Preformulation strategy, Analytical method development (HPLC, LC-MS), Developability risk assessment, Physicochemical characterization, Solubility and stability studies, Regulatory documentation (IND/NDA), Technical mentoring, Cross-functional collaboration
Preferred skills
LC-MS expertise, Agilent OpenLab software proficiency, Knowledge of diverse dosage forms (parenteral, oral solutions, SDD, HME, SEDDS)
Technologies
HPLC (SEC, UV, MS, IEX), LC-MS, MS-MS, SEC-HPLC, DSC, TGA, PXRD, NMR, Particle-Size Analysis, GVS, PLM, SEM
Responsibilities
Design and execute preformulation and developability studies; Develop fit-for-purpose analytical methods; Evaluate experimental findings to recommend formulation strategies; Provide independent scientific review of data and reports; Mentor scientists on experimental approaches and data interpretation; Collaborate with multidisciplinary R&D teams to anticipate downstream challenges; Author technical reports and regulatory submissions.
Seniority
Principal, hands-on IC with strategic guidance
