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Clinical Lead Early Clinical and Experimental Therapeutics Oncology

Cambridge, MA, US💼 Full-time🗓 2026-09-18 → 2026-09-25

Core

Lead early clinical development of oncology assets (small molecules, mAbs, ADCs, immune cell engagers) for solid tumors and hematologic malignancies, focusing on First-In-Human studies, Proof-of-Mechanism, and Human Target Validation.

Role type

Senior Clinical Lead, Early Clinical and Experimental Therapeutics (Oncology)

Builds

Early clinical development plans and execution for novel oncology therapeutics

Domain

Oncology, Translational Medicine, Early Phase Clinical Trials

Deliverable

production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work

Required skills

Protocol design for FIH studies, Dose escalation management, Safety monitoring, Regulatory document authoring, Cross-functional team leadership, CRO oversight, Data interpretation for Go/No-Go decisions

Preferred skills

MD + PhD, Experience in Phase 1/2a trials, Pre-clinical data interpretation, Biomarker data analysis

Technologies

None explicitly listed

Responsibilities

Design First-In-Human and mechanistic studies, Make front-line decisions on protocol execution and safety, Supervise study execution and medical monitoring, Author clinical protocols and regulatory documents, Lead dose escalation meetings, Oversee CROs and external partners, Present data at scientific meetings

Seniority

Senior, hands-on IC with strategic decision-making authority

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