Principal Scientist
Core
Lead scale-up of cell culture bioprocesses from bench to pilot/manufacturing scales (200L–2000L) for advanced cell and gene therapy products including AAV and lentiviral vectors.
Role type
Senior individual contributor, upstream bioprocess scale-up scientist
Builds
Robust, scalable cell culture processes for genomic medicine pipeline
Domain
Biopharmaceuticals / Cell and Gene Therapy / Upstream Bioprocessing
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Large-scale bioreactor operations, cell culture process development, perfusion process operations, engineering principles for mixing/mass transfer/shear stress, root cause analysis, technical leadership
Preferred skills
AAV manufacturing experience, mammalian cell culture metabolism optimization, process automation, cross-functional team management
Technologies
Large-scale bioreactors, perfusion systems, process automation tools
Responsibilities
Lead scale-up activities applying engineering principles, collaborate on translating lab findings to manufacturing, review and approve JSAs, train employees on safety and best practices, build interfaces with CMC community, lead root cause analysis for deviations, present results to senior management and external stakeholders
Seniority
Senior, hands-on IC with technical leadership
