Principal Scientist
Core
Lead scale-up activities from bench to pilot scale (200L–2000L) for advanced cell and gene therapy products, ensuring process comparability and operational excellence.
Role type
Senior individual contributor, upstream bioprocess scale-up scientist
Builds
Robust, scalable manufacturing processes for recombinant AAV vectors, lentiviral vectors, and cell therapy products
Domain
Biopharmaceuticals / Cell and Gene Therapy / Upstream Bioprocessing
Required skills
Large-scale bioreactor operations, scale-up technologies, perfusion process operations, upstream process operations, root cause analysis, engineering principles (mixing, mass transfer, shear stress), process development
Preferred skills
Cross-functional team management, AAV manufacturing process development, mammalian cell culture, cell metabolism/media optimization, process automation
Technologies
Bioreactors, perfusion systems, upstream processing equipment
Responsibilities
Lead scale-up activities from bench to pilot scale, collaborate on translating lab findings to manufacturing, review and approve JSAs, train employees on safety and best practices, build interfaces with CMC community, lead root cause analysis for deviations, present findings to senior management and stakeholders
Seniority
Senior, hands-on IC with technical leadership