Scientist, Protein Design
Core
Lead design and execution of high-throughput mammalian cell-based screening platforms for viral and bacterial antigens to enable antigen optimization and rapid maturation of computationally designed candidates.
Role type
Senior Scientist, Protein Design & In Vitro Selection
Builds
Scalable high-throughput mammalian display screening systems and datasets for computational design teams
Domain
Biopharma / mRNA therapeutics / Protein Engineering
Required skills
Mammalian display systems, high-throughput selection strategies, experimental assay design, library design and construction, NGS-based readouts, quantitative enrichment analysis
Preferred skills
Antigen expression and engineering, folding and trafficking optimization, glycan impact analysis, directed-evolution capabilities
Technologies
Mammalian cell lines, NGS platforms, DNA assembly methods, high-throughput screening hardware
Responsibilities
Lead execution of in vitro selection and cell-surface screening campaigns, design and run high-throughput mammalian display campaigns for complex glycoproteins, build and deploy scalable screening systems replacing plate-based assays, serve as experimental partner to computational protein design teams, represent in vitro selection capabilities in cross-functional discovery discussions
Seniority
Senior, hands-on IC