Senior Associate Scientist, Purification, RNA Process Development
Core
Designing efficient, robust, and scalable manufacturing processes for circular and linear mRNA drug substances, focusing on chromatography and filtration steps.
Role type
Senior Associate Scientist (Process Development)
Builds
RNA drug substance purification processes for early- to late-stage development
Domain
Biopharmaceuticals / mRNA therapeutics
Required skills
Chromatography, Filtration (TFF/UF-DF), Statistical design of experiments (DoE), Process analytics, Biophysical characterization (HPLC, CE, gel electrophoresis), cGMP/QbD principles
Preferred skills
Scale down models, Mechanistic models, Nucleic acid chemistry, Lipid chemistry, Upstream process characterization
Technologies
HPLC, CE, Gel electrophoresis, TFF, UF-DF
Responsibilities
Execute and analyze experiments for existing and novel process modes, Support RNA drug substance purification process definition and scale up, Collaborate with analytical teams to characterize RNA properties and impurity profiles, Participate in tech transfer activities to GMP manufacturing sites, Prepare technical reports and communicate findings
Seniority
Mid-Senior, hands-on IC