Senior Research Investigator, Pharmacometrics
Core
Develop and implement model-informed drug development (MIDD) plans using pharmacometrics (PMx) models to inform clinical study hypotheses, dose selection, and regulatory assessments.
Role type
Senior IC pharmacometrician (MIDD)
Builds
Population pharmacokinetics/pharmacodynamics, exposure-response, disease progression, and model-based meta-analyses (MBMA) models
Domain
Biopharmaceuticals / Pharmacometrics
Deliverable
production ML models
Required skills
Population pharmacokinetics (PPK), exposure-response (E-R), data wrangling, advanced statistical analysis, R, NONMEM, Monolix, Pumas, Matlab, Python, Julia
Preferred skills
Mechanistic modeling (QSP, PBPK), scientific machine learning, agentic workflows
Responsibilities
Partner with Clinical Pharmacology leads to specify MIDD components; execute formal PMx analyses for regulatory submissions; manage vendor-performed PMx analyses; serve as MIDD SME for health authority interactions; contribute to PMx infrastructure maintenance.
Seniority
Senior, hands-on IC