Principal Scientist, Cardiovascular Translational Biomarker
Core
Identify and discover novel and existing biomarkers to support the progression of late-discovery cardiovascular programs to early phase clinical trials.
Role type
Principal Scientist, Cardiovascular Translational Biomarker
Builds
Therapeutics for cardiovascular patients
Domain
Cardiovascular biology and translational medicine
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
cardiovascular physiology, experimental design, cell culture (iPSC-CM, primary cardiac cells), immunoassays (ELISA/MSD, IHC), qPCR, imaging biomarkers (ultrasound-echocardiography, MRI, PET), animal research (3Rs principles), rodent handling, biochemical/functional measurements in engineered heart tissues
Preferred skills
post-doctoral training, managing external collaborators (CROs), authoring scientific reports and publications
Technologies
ELISA, MSD, IHC, qPCR, MRI, PET, ultrasound-echocardiography
Responsibilities
Perform studies to define pharmacodynamic biomarkers of response and disease progression; lead studies to completion including hands-on analysis or directing external CROs; evaluate programs critically and present findings to leadership; document, review, and modify experimental approaches; provide hands-on training and guidance to team members; contribute to and author reports, abstracts, and publications
Seniority
Principal, hands-on IC with mentorship
