Principal Scientist, Pharmaceutical Development
Core
Principal Scientist leading pharmaceutical development, developability science, and formulation strategy to mitigate risks and accelerate drug candidates from discovery to development using experimental, computational, and AI-enabled approaches.
Role type
Principal Scientist, Pharmaceutical Development (Strategy & Hands-on IC)
Builds
Drug candidates progressing from discovery into development for clients in pharma/biotech
Domain
Pharmaceutical Sciences / Drug Discovery / Biopharmaceutics
Required skills
Developability science, Formulation strategy, Physicochemical sciences, Biopharmaceutics, Solid-state science, Drug delivery, AI-enabled approaches, Data interpretation, Scientific project leadership, Client engagement
Preferred skills
Model-informed formulation design, Computational/Predictive modeling, PK data interpretation, Mechanistic developability (DCS, PBPK), Solubility/dissolution/absorption risk evaluation, Non-oral dosage routes, Beyond Rule of 5 compounds
Technologies
AI-enabled tools, Computational modeling frameworks, PBPK, DCS
Responsibilities
Design and oversee developability studies, Integrate physicochemical and formulation data, Apply AI/computational approaches for risk assessment, Translate insights into recommendations, Recommend formulation strategies, Lead multidisciplinary drug discovery projects, Act as primary scientific contact for clients, Mentor junior scientists
Seniority
Principal, strategic leadership with hands-on execution
