Scientist, Drug Metabolism
Core
Scientist supporting PK and PK/PD modeling across discovery and development for large-molecule therapeutics, including biologics, ADCs, and multispecific/T-cell engagers.
Role type
Scientist, Drug Metabolism (PK/PD Modeling)
Builds
Quantitative DMPK strategies, mechanistic PK/PD models, and simulation workflows for study design and human PK/dose predictions.
Domain
Biopharmaceuticals / Drug Metabolism and Pharmacokinetics (DMPK)
Deliverable
production ML models
Required skills
Quantitative PK/PD modeling, mechanistic modeling, TMDD, target engagement, nonclinical study design, AI-based modeling workflows, regulatory submission support, large-molecule disposition
Preferred skills
Engineering or pharmacology degree concentration, experience with biologics/ADCs/multispecific antibodies/T-cell engagers
Technologies
Phoenix/WinNonlin, MATLAB/SimBiology, R, GastroPlus
Responsibilities
Provide PK and PK/PD modeling support across discovery and development; Contribute to quantitative DMPK strategies by working with interdisciplinary project teams; Develop and apply mechanistic PK/PD models to address translational questions; Develop and apply modeling and simulation workflows incorporating AI-based approaches; Analyze and communicate modeling results and recommendations to project teams; Work with project teams, line management, and CROs to support regulatory submissions; Contribute quantitative modeling expertise to business development and licensing evaluations
Seniority
Mid-Senior level (PhD 0+ years or Masters 4+ years industry experience)
