Senior Scientist, Protein Therapeutics
Core
Strengthen Antibody Drug Conjugate (ADC) analytics capabilities and build the analytical foundation to support discovery and candidate selection across oncology, inflammation, and virology programs.
Role type
Senior Scientist, Protein Therapeutics (ADC Analytics)
Builds
Analytical characterization data and developability assessments for ADC candidates
Domain
Biopharmaceuticals / Oncology / Protein Therapeutics
Required skills
Mass spectrometry (intact and subunit), peptide mapping, multidimensional chromatography, ADC developability assessment, experimental design, data integrity management, scientific publication
Preferred skills
Native and denaturing LC-MS, HIC, SEC, RP, IEX, CE-SDS, cIEF, linker-payload platform expertise, ADC pharmacokinetics and metabolism knowledge, biophysical data application
Technologies
LC-MS, HIC-RP-MS, SEC-RP-MS, IEX-RP-MS, 2D-LC, ELN
Responsibilities
Design and execute analytical characterization experiments for ADCs, develop and optimize advanced analytical methods, evaluate key ADC attributes (DAR, aggregation, fragmentation, etc.), resolve complex analytical challenges, implement emerging analytical technologies, mentor junior scientists
Seniority
Senior, hands-on IC with mentorship responsibilities
