Senior Scientist, Drug Metabolism
Core
Expert in pharmacokinetic (PK) and PK/Pharmacodynamic (PD) modeling of small molecules and biologics, providing strategic input on discovery and development project teams.
Role type
Senior Scientist, Drug Metabolism (PK/PD Modeling)
Builds
Mathematical models for ADME characterization, dose selection, and clinical translation of therapeutics.
Domain
Biopharmaceuticals / Drug Discovery & Development
Deliverable
production ML models | product features
Required skills
PK and PD principles, mechanistic PK/PD modeling, multi-compartmental modeling, quantitative modeling of agents (small molecules, biologics, ADCs, degraders), study design and interpretation, regulatory document preparation
Preferred skills
AI workflows for model-building and automation, external visibility through publications/presentations
Technologies
Phoenix/WinNonlin, MATLAB/SimBiology, GastroPlus, R
Responsibilities
Provide advanced PK/PD modeling expertise guiding nonclinical study design; Drive quantitative DMPK strategy for programs; Design and validate complex PK/PD models to support dose selection; Develop modeling workflows with AI enhancements; Collaborate with CROs for regulatory submissions; Participate in business development evaluations
Seniority
Senior, hands-on IC