Research Fellow [LKCMedicine]
Core
Develop and validate a colon cancer model using vascularized patient-derived organoid platforms for intravascular dosing and real-time imaging.
Role type
Research Fellow (Vascularized Organoids & Microphysiological Systems)
Builds
Kit-ready vascularized organoid platforms for solid-tumor biology and therapy response
Domain
Bioengineering and translational cancer biology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
3D culture systems, patient-derived organoids, microfluidics, perfusable/vascular co-culture models, ECM hydrogel handling, confocal microscopy, image quantification, flow cytometry
Preferred skills
single-cell RNA-seq sample preparation, spatial profiling, basic scRNA-seq data interpretation
Technologies
5-FU, collagen, fibrin, confocal microscopy, flow cytometry, single-cell RNA-seq
Responsibilities
Establish and quality-control patient-derived colorectal cancer organoids; Set up and optimize vascularized organoid cultures; Execute intravascular dosing assays; Perform live/dead imaging and sample retrieval for downstream analyses; Conduct tissue dissociation and immune/phenotypic profiling workflows; Coordinate external core services for single-cell and spatial profiling; Manage project operations including procurement and reporting; Contribute to research outputs including manuscripts and patent documentation
Seniority
Mid-level Research Fellow, hands-on IC
