CareerPlan

Senior Principal Scientist, Skin Biology and Inflammation

US - California - South San FranciscoFull-time2026-10-27 → 2026-11-10

Core

Senior scientific leader in skin biology shaping therapeutic hypotheses and programs for inflammatory diseases, connecting experimental biology with human data, computation, and AI.

Role type

Senior Principal Scientist (Scientific Leadership)

Builds

Integrated experimental and computational strategies for target identification, validation, and differentiated therapeutic approaches in skin inflammation.

Domain

Biotechnology / Dermatology / Inflammation Research

Deliverable

production ML models

Required skills

Keratinocyte biology, stem cell biology, stromal and fibroblast biology, epithelial-neuro-immune interactions, AI-enabled computational approaches, spatial and single-cell approaches, perturbational biology, program strategy, cross-functional leadership

Preferred skills

Organotypic models, multi-omics, functional genomics, drug discovery program advancement, scientific influence (publications/patents)

Technologies

AI-enabled tools, machine learning, advanced analytics, high-content phenotyping, next-generation tissue models

Responsibilities

Define human-biology-driven hypotheses for target identification; design and interpret complex studies using human tissues and advanced preclinical systems; apply AI and data science to synthesize evidence and prioritize experiments; identify and implement emerging technologies; guide program strategy and milestone definition; coach colleagues and foster research culture; communicate scientific strategy to senior leaders and external audiences.

Seniority

Principal, strategy & mentorship