Scientist III, Chemistry
Core
Design, synthesize, purify, and characterize modified oligonucleotide constructs and dyes for real-time PCR and molecular biology R&D programs.
Role type
Senior IC organic/oligonucleotide chemist
Builds
Novel dyes and functionalized oligonucleotide constructs for Genetic Sciences Division R&D and new product development
Domain
Life Sciences / Oligonucleotide Chemistry / Molecular Biology
Required skills
Oligonucleotide synthesis, HPLC, LC-MS, real-time PCR, chemical conjugation (NHS ester, click chemistry), experimental design, data analysis
Preferred skills
Automated DNA/RNA synthesizers, fluorescent probe design, assay optimization, industrial R&D experience
Technologies
HPLC, LC-MS, real-time PCR instruments, automated synthesizers
Responsibilities
Design and synthesize modified oligonucleotides; perform automated synthesis and purification; characterize constructs using HPLC/LC-MS; execute real-time PCR experiments to evaluate performance; troubleshoot synthesis and functionalization challenges; develop optimization methods for dye labeling and conjugation; collaborate on technology transfer and process development.
Seniority
Senior, hands-on IC
