Lead Researcher - Experimental Leukemia Modeling, Mullighan Lab
Core
Lead research into the biologic basis of fusion oncoprotein-driven acute lymphoblastic leukemia (ALL) to develop improved therapies for children.
Role type
Lead Researcher (Experimental Leukemia Modeling)
Builds
In vitro and in vivo leukemia models, therapeutic targets, and translational approaches.
Domain
Oncology / Molecular Biology / Structural Biology / Functional Genomics
Required skills
Molecular biology, Cell culture, Flow cytometry, DNA/RNA isolation, Western blotting, Functional assays, Proteomics, Structural biology, Functional genomics, In vivo modeling
Preferred skills
Genomics, Cancer models, R&D methods, Lab project execution
Technologies
PCR, Xenograft models, Engineered leukemia models
Responsibilities
Perform molecular and cell biology experiments to investigate fusion oncoprotein-driven ALL mechanisms; Conduct DNA/RNA isolation, PCR-based assays, and Western blotting; Perform flow cytometry and functional assays to evaluate cellular phenotypes and therapeutic responses; Contribute to leukemia modeling using in vitro and in vivo approaches; Apply proteomics, structural biology, and functional genomics to identify therapeutic targets; Analyze and document experimental data.
Seniority
Senior, hands-on IC