Senior Scientist or Scientist - Drug Metabolism and Pharmacokinetics (DMPK)
Core
Conduct laboratory-based DMPK studies (bioanalysis, in vitro assays, in vivo PK) to support small-molecule drug discovery and development.
Role type
Senior Scientist or Scientist, Drug Metabolism and Pharmacokinetics (DMPK)
Builds
Preclinical data supporting PK/PD, ADME, and efficacy evaluations for small-molecule drugs
Domain
Pharmaceutical research / Drug discovery
Required skills
LC-MS/MS bioanalysis, in vitro DMPK assays (protein binding, microsomal stability, hepatocyte metabolism, permeability), in vivo PK study execution, preclinical formulation, data analysis, LIMS management
Preferred skills
SCIEX instrumentation experience
Technologies
LC-MS/MS, LIMS, cell monolayers, microsomes, hepatocytes
Responsibilities
Perform quantitative LC-MS/MS bioanalysis of small/large molecules; Execute in vitro DMPK assays; Conduct in vivo PK studies (dosing, sampling, tissue collection); Develop preclinical formulations; Analyze data and maintain records; Communicate results to the Director and project team
Seniority
Senior Scientist (10+ years) or Scientist (3-8 years depending on degree)