Postdoctoral Research Fellow - DNA/Aptamer Chemist
Core
Design, synthesis, modification, and biophysical characterization of DNA aptamers for prostate cancer treatment.
Role type
Postdoctoral Research Fellow (DNA/Aptamer Chemist)
Builds
Nucleic acid-based targeting agents for cancer therapy
Domain
Academic research in chemical biology and oncology
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Oligonucleotide/DNA chemistry, Solid-phase oligonucleotide synthesis, Nucleic acid modification and conjugation, Aptamer development or SELEX, Protein-ligand binding assays, Bioanalytic techniques (SPR, BLI, MST, ITC, HPLC, LC-MS), Structure-function analysis of nucleic acids, Nucleic acid-protein interactions
Preferred skills
Radiochemistry, Chelator chemistry, Structural biology, Therapeutic oligonucleotide development
Technologies
HPLC, LC-MS, SPR, BLI, MST, ITC
Responsibilities
Design and synthesis of DNA aptamers and modified oligonucleotides, Solid-phase oligonucleotide synthesis, purification and quality control, Chemical modification and functionalization of DNA, Purification and analytical characterization, Systematic structure-function studies, Development of aptamers with improved affinity, selectivity and stability, Quantitative characterization of aptamer-protein interactions, Conjugation of aptamers to imaging or therapeutic payloads, Collaboration with multidisciplinary research teams
Seniority
Postdoctoral Research Fellow (12-month term with extension possibility)