Senior Liver Tissue Engineer
Core
Develop, optimize, and characterize liver-specific micro-physiological (MPS) and organ-on-chip models for toxicity, metabolism, and disease-state studies using advanced in vitro tissue culture systems.
Role type
Senior Liver Tissue Engineer (Research & Development)
Builds
Micro-physiological systems (organ-on-chip) and in vitro tissue culture platforms for biomedical research and defense applications.
Domain
Biomedical engineering / Tissue engineering / Micro-physiological systems
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
Cell culture (primary liver cells, iPSC-derived hepatocytes), Micro-physiological system (MPS) operation, Molecular and biochemical assays (ELISA, qPCR, flow cytometry), Immunostaining, Image analysis (confocal microscopy), SOP development, Data analysis (multi-omics, biostatistics), Troubleshooting experimental challenges, Proposal writing
Preferred skills
Liver-specific expertise (3D organoids, microfluidic devices, perfused bioreactors), Complex hepatic co-culture (Kupffer, stellate, sinusoidal endothelial cells), AI/ML-driven cell painting, Bioinformatics (R/Python), In silico PK/PD modeling, Lab automation, Grant writing, Patent generation
Technologies
Microfluidic devices, Perfusion bioreactors, Confocal microscopy, Luminex, Flow cytometers, qPCR systems, R, Python
Responsibilities
Culture and manipulate human primary liver cells and tissues within MPS platforms; Perform molecular, biochemical, and cellular assays; Acquire and analyze microscopy data; Create and maintain SOPs; Collaborate on project plans and mentor colleagues; Troubleshoot experimental challenges; Contribute to business development and proposal writing; Support lab organization and compliance.
Seniority
Senior, hands-on IC with mentorship responsibilities
