Scientist II, Degrader Antibody Conjugate Characterization
Core
Lead the development of innovative analytical workflows for Degrader Antibody Conjugate (DAC) platforms, designing high-throughput screening and characterization strategies to support drug discovery and candidate selection.
Role type
Senior IC analytical scientist (DAC/ADC characterization)
Builds
Analytical workflows and quality criteria for targeted protein degradation therapeutics
Domain
Biopharmaceuticals / Targeted Protein Degradation
Required skills
ADC/DAC characterization, LCMS method development, HPLC method development, peptide mapping, glycosylation analysis, stability testing, assay design, data interpretation, cross-functional collaboration
Preferred skills
Native LCMS, positional isomer analysis, CE-SDS, biophysical binding assays, thermal stability, developability assessment, Agilent instrumentation
Technologies
LCMS, HPLC, SEC, HIC, MassHunter, Byos
Responsibilities
Design and execute DAC screening characterization platforms including DAR, aggregation, and protein quantitation; Lead in-depth characterization of antibodies and advanced DACs including positional isomers and stability; Integrate analytical data into unified assessments to drive go/no-go decisions; Develop and optimize LCMS/HPLC methods for throughput and robustness; Present findings and collaborate with chemistry and bioanalytical teams to align workflows
Seniority
Senior, hands-on IC
