Principal Engineer
Core
Building the digital and AI platform that powers drug discovery and scientific research across the Flagship Pioneering ecosystem.
Role type
Principal Software Engineer (AI/ML platform)
Builds
AI-powered product areas including scientific workflow tools, data infrastructure, and agentic AI systems
Domain
Biotech / AI / Drug Discovery
Deliverable
production ML models | product features | infrastructure
Required skills
System architecture design, AI-native engineering (LLM orchestration, agentic workflows), production-grade software development, data pipeline design, root-cause analysis, technical decision-making in ambiguous environments
Preferred skills
Experience bridging experimental models and production software, familiarity with AI tools as force multipliers, ability to coordinate embedded contractors
Technologies
LLMs, agentic AI systems, data infrastructure, API contracts, observability tools
Responsibilities
Own technical architecture and implementation for AI-powered product areas; Design and build production-grade systems end-to-end; Engage directly with scientific and ML users to translate needs into software; Make highest-stakes technical decisions on system architecture and integration patterns; Collaborate with product and ML science counterparts on strategy; Participate in architectural reviews across the engineering team
Seniority
Principal, hands-on IC with technical authority
