Senior Director, RNAi Discovery
Core
Lead the end-to-end siRNA discovery engine, from bioinformatic library design and off-target assessment through chemistry optimization, in vitro screening, and scale-up for in vivo evaluation.
Role type
Senior Director, RNAi Discovery (Hands-on scientific leadership)
Builds
siRNA discovery platform and development candidates for RNAi therapeutics
Domain
Biotechnology / RNAi therapeutics / Oligonucleotide chemistry
Required skills
siRNA library design, off-target analysis, siRNA chemistry optimization, in vitro assay development, in vivo PK/PD study design, CMC translation, data analysis (Python/R), team leadership
Preferred skills
Building a discovery platform from the ground up
Technologies
Python, R
Responsibilities
Define and execute siRNA discovery strategy from target nomination to candidate selection; Lead bioinformatic design of siRNA libraries and off-target analysis; Manage external vendors for library generation; Lead chemistry optimization of hits for potency and safety; Build and lead the in vitro screening organization; Establish the hit-to-lead cascade; Scale up lead siRNAs and coordinate in vivo PK/PD studies; Provide technical knowledge to CMC partners for manufacturing scalability.
Seniority
Senior Director, hands-on scientific leadership