Scientist II, Process Chemistry
Core
Laboratory-based process chemist owning development workstreams for a small-molecule drug substance, designing experiments to optimize reactions and develop robust processes for scale-up and technology transfer.
Role type
Senior IC process chemist
Builds
Robust manufacturing processes for oral RAS(ON) inhibitors
Domain
Oncology / Pharmaceutical process chemistry
Required skills
Multistep synthesis, reaction optimization, isolation, crystallization, NMR, chromatography, mass spectrometry, mechanistic reasoning, electronic laboratory notebooks, ChemDraw
Preferred skills
CDMO technology transfer, design of experiments, automated laboratory reactors, cGMP manufacturing, regulatory documentation
Responsibilities
Design and execute experiments to evaluate alternative routes and optimize reactions, workup, isolation, and crystallization conditions; Develop robust processes by defining parameter sensitivity, reproducibility, impurity control, and solubility limits; Plan and execute laboratory studies and translate results into recommendations for process implementation at large-scale; Prepare technology transfer procedures and work with external CDMOs to resolve implementation issues; Author process development reports and technical content supporting regulatory documentation; Provide scientific guidance to research associates and identify laboratory and process safety risks
Seniority
Senior, hands-on IC
