Senior PBPK Modeler
Core
Develop and validate physiologically based pharmacokinetic (PBPK) models to predict human PK and optimize dosing strategies for novel drug candidates (antibodies, small molecules, oligonucleotides).
Role type
Senior IC PBPK Modeler
Builds
Physiologically based pharmacokinetic (PBPK) models for drug development decision-making
Domain
Biotechnology / Pharmacokinetics
Deliverable
production ML models
Required skills
PBPK modeling, ADME properties, parameter estimation, model validation, clinical dosing regimen proposal, variability incorporation, multi-modality modeling (antibodies, small molecules, oligonucleotides)
Preferred skills
Multi-specific antibodies, extended half-life biologics, clinical trial design support, regulatory submissions
Technologies
Simcyp, GastroPlus, PK-Sim, Phoenix WinNonLin, R, Python, MATLAB
Responsibilities
Develop and refine PBPK models using in vitro and preclinical data; Compare and validate models using published clinical PK data; Propose clinical dosing regimens based on model outputs; Analyze model predictions to identify key parameters; Collaborate to integrate experimental data into workflows; Address discrepancies between preclinical and human PK predictions; Incorporate variability (age, weight, genetics) into models; Adapt modeling approaches for different drug modalities.
Seniority
Senior, hands-on IC
