Clinical Histocompatibility Scientist (CHS)
Core
Perform high-complexity HLA testing including typing, antibody screening, and crossmatching to support transplant compatibility.
Role type
Clinical Histocompatibility Scientist (CHS)
Builds
HLA typing results, antibody identification reports, and crossmatch outcomes for transplant candidates.
Domain
Clinical diagnostics / Immunohematology / Transplant medicine
Deliverable
production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work
Required skills
HLA typing (NGS, SSP, RT-PCR), HLA antibody screening (FlowPRA, Luminex, SAB), virtual and physical crossmatching, specimen processing (blood, serum, DNA, tissues), instrument operation (Luminex, NGS, qPCR, flow cytometry), quality control, proficiency testing, assay validation, LIMS/LIS system usage
Preferred skills
ASHI-accredited HLA laboratory experience, Flow cytometry crossmatching, Luminex One Lambda platform familiarity, SAB assay interpretation, transplant matching algorithms understanding, method validation experience
Technologies
NGS sequencers, Luminex platforms, qPCR instruments, Flow cytometers, LIMS/LIS systems
Responsibilities
Perform HLA typing and antibody screening; analyze and document test results per ASHI standards; operate and troubleshoot specialized instruments; perform QC and proficiency testing; assist with assay validations; participate in workflow improvement and CAPA; support staff training; perform on-call duties
Seniority
Mid-level, hands-on IC