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MSAT Technical Lead – Drug Substance (Sr Manager)

Waltham, MA, us💼 Full-time💰 $140,000–$140,000🗓 2026-06-24 → 2026-07-31

Core

Lead technical aspects of small molecule drug substance manufacturing, process validation, and lifecycle management for clinical and commercial products.

Role type

Senior Manager, Small Molecule Drug Substance Manufacturing

Builds

Validated manufacturing and analytical processes for rare disease therapies

Domain

Biopharmaceuticals / Small Molecule Drug Substance Manufacturing

Deliverable

production ML models | product features | dashboards & analysis | research | client delivery | infrastructure | physical/clinical work

Required skills

Small molecule drug substance development and manufacturing, Process validation (APR/PQR), Regulatory guidelines and file documentation, External vendor management (CMOs/CDMOs), Cross-functional team leadership, Risk assessment and CAPA management, Technology scouting for process innovation

Preferred skills

Experience with market expansion and variations, Scale-up activities, Cost and yield improvement strategies

Technologies

CMC development tools, Manufacturing execution systems, Regulatory submission platforms

Responsibilities

Serve as SME for small molecule drug substance manufacturing, Lead MSAT projects for process and cost improvement, Review and approve SOPs and manufacturing instructions, Supervise technical studies and validations, Lead product transfer and scale-up activities, Support sourcing and evaluation of new contract manufacturers

Seniority

Senior Manager, hands-on technical leadership

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