Associate Principal Scientist – Process Analytical Technology and Chemometrics
Core
Expert support for continuous manufacturing of commercial drug products using Process Analytical Technology (PAT) and chemometrics to ensure efficient multi-site operations and robust control strategies.
Role type
Associate Principal Scientist (Process Analytical Technology and Chemometrics)
Builds
PAT frameworks, chemometric models, and control strategies for on-market pharmaceutical products.
Domain
Pharmaceutical manufacturing / Chemometrics / Multivariate Data Analysis
Deliverable
production ML models
Required skills
Chemometrics, Multivariate Data Analysis (MVDA), Machine Learning, PAT orchestration (SIPAT/SynTQ), PAT interface with commercial processes, Business strategy for PAT/MSPC integration, Technology transfer in pharma, Vibrational spectroscopy (NIR, Raman, microwave resonance), Chemometric modelling software (SIMCA, Unscrambler, MATLAB), Safety, Health & Environment (SHE) management.
Preferred skills
Training teams on PAT tools, Cross-site project leadership, Digital Twins and Simulation models, Separation science, NMR, Mass spectrometry, Lean problem-solving tools.
Technologies
SIMCA, Unscrambler, MATLAB, SIPAT, SynTQ
Responsibilities
Manage lifecycle of chemometric models for commercial drug products; Identify and implement PAT opportunities to evolve control strategies; Provide technical leadership for resolving PAT instrument/model manufacturing issues; Develop corrective and preventive actions for PAT investigations; Support impact or transfer of PAT methods to internal or external partners; Define business strategy for PAT/MSPC integration; Lead stakeholder engagement for new PAT technology implementation.
Seniority
Senior, hands-on IC
