Senior / Principal Scientist, Medicinal Chemistry
Core
Design and synthesize novel small-molecule compounds to advance drug discovery programs from hit identification to lead optimization.
Role type
Senior/Principal Medicinal Chemist (small-molecule drug discovery)
Builds
Drug-like molecules and optimized compounds for candidate selection
Domain
Biotechnology / Medicinal Chemistry
Required skills
Organic synthesis, structure-based drug design, SAR analysis, multi-step synthesis planning, CRO management, compound characterization
Preferred skills
Lead author publications, patents, experience with machine learning tools in drug discovery
Technologies
Structure-based design tools, computational design tools, CRO platforms
Responsibilities
Design and synthesize novel compounds; analyze SAR data to drive design; collaborate with DMPK, structural biology, and ML teams; manage external CRO chemistry FTEs; troubleshoot synthetic issues
Seniority
Senior/Principal, hands-on IC with potential for program leadership