Scientist, mRNA Analytical Development
Core
Lead the development of analytical methods to characterize DNA templates and mRNAs for a biotechnology company developing epigenetic reprogramming medicines.
Role type
Senior IC analytical scientist (mRNA)
Builds
Analytical methods and assays for DNA template and mRNA drug substance release and characterization
Domain
Biotechnology / mRNA therapeutics / Analytical Chemistry
Required skills
Assay development and qualification, HPLC separations (IP-RP-HPLC, SEC), capillary electrophoresis, plate-based assays (qPCR, ELISA), experimental design and troubleshooting, technical writing
Preferred skills
Method lifecycle management, sequencing workflows (Sanger, Oxford Nanopore), cell-based potency assays, LC-MS assays, CDMO method transfer
Technologies
HPLC, SEC, qPCR, ELISA, Sanger sequencing, Oxford Nanopore Technologies, LC-MS
Responsibilities
Develop and establish analytical methods for DNA template and mRNA characterization, Lead studies to evaluate method robustness and set performance criteria, Perform routine testing of DNA templates and mRNA materials, Investigate impurities and degradation, Author method protocols and technical reports, Manage outsourcing of advanced analytical techniques to CROs
Seniority
Mid-level IC (0-3 years PhD or 5+ years MS/BS)